Enabled by a novel and powerful combination of live-cell STED imaging, electrophysiology, function-blocking antibody and targeted genetic deletion, the project aims to substantially advance our understanding of the functional interactions between astrocytes and neurons at synapses. It addresses several fundamental questions about the role of the different IP3 receptor subtypes and the endoplasmic reticulum to astroglial calcium signalling and gliotransmission under realistic experimental conditions.

Find out more about the project on Misa Arizono's personal website.