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Team : CHOQUET

Research Projects

Team Project Summary

Project Leader(s): Anna Brachet, Daniel Choquet, Françoise Coussen, Eric Hosy, Matthieu Sainlos

We have a transdisciplinary approach to study the interplay between the organizational dynamics of the molecular components

of glutamatergic synapses and synaptic transmission. Our projects build on our recent findings that:

  • trafficking of neuronal molecules such as glutamate receptors is highly dynamic,
  • regulations of protein-protein interactions play key roles in the control of this trafficking at different steps, including lateral diffusion, endo and exocytosis,
  • modulation of glutamate receptor trafficking has a profound impact on synaptic transmission, including on both short and long term post-synaptic plasticity.

By combining the expertise of chemists, biochemists, cell biologists, biophysicists and neurophysiologists, we will develop 3 main research axes:

  • dynamics and physical-chemistry of the macro-molecular complexes of the synapse,
  • nano-scale organization and dynamics of synaptic proteins and membrane trafficking,
  • impact of the dynamic of synapse organization on synaptic physiology.

Results obtained in these three axes will be constantly integrated to provide a global view of glutamatergic synapse physiology, from nano-scale interactions to function up to higher brain functions such as memory formation and retrieval.

Fundings

Our team is funded by ERC Advanced Grant Dyn-Syn-Mem, several ANR grants, and funding from the Regional Council of Aquitaine, Fondation pour la Recherche Médicale, etc...

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