Team : CHOQUET
Team Project Summary
Project Leader(s): Anna Brachet, Daniel Choquet, Françoise Coussen, Eric Hosy, Matthieu Sainlos
We have a transdisciplinary approach to study the interplay between the organizational dynamics of the molecular components
of glutamatergic synapses and synaptic transmission. Our projects build on our recent findings that:
- trafficking of neuronal molecules such as glutamate receptors is highly dynamic,
- regulations of protein-protein interactions play key roles in the control of this trafficking at different steps, including lateral diffusion, endo and exocytosis,
- modulation of glutamate receptor trafficking has a profound impact on synaptic transmission, including on both short and long term post-synaptic plasticity.
By combining the expertise of chemists, biochemists, cell biologists, biophysicists and neurophysiologists, we will develop 3 main research axes:
- dynamics and physical-chemistry of the macro-molecular complexes of the synapse,
- nano-scale organization and dynamics of synaptic proteins and membrane trafficking,
- impact of the dynamic of synapse organization on synaptic physiology.
Results obtained in these three axes will be constantly integrated to provide a global view of glutamatergic synapse physiology, from nano-scale interactions to function up to higher brain functions such as memory formation and retrieval.
Our team is funded by ERC Advanced Grant Dyn-Syn-Mem, several ANR grants, and funding from the Regional Council of Aquitaine, Fondation pour la Recherche Médicale, etc...