Olfaction and Memory

Expertise
News
Selected Publications
Members
Jobs
Alumni & Guests

Team Leader : Lisa Roux

General objective

Chemosensation is a fundamental sensory modality for living organisms, ranging from Bacteria to Mammals. It is used for many vital functions such as spatial navigation and communication with conspecifics. Odors can trigger innate behavioral responses, but most odor stimuli acquire behavioral significance upon learning and experience. The overarching goal of our team is to identify the neurophysiological substrates of olfactory memory formation across distributed brain networks.

To reach this goal, we study rodents in naturalistic conditions using cutting-edge technologies that allow recording and manipulating large neuronal ensembles in behaving animals: single unit extracellular recordings with silicon probes, closed-loop optogenetic strategies, automated behavioral tracking and precise monitoring of sniffing behavior.

Research Projects

Role of oxytocin in the piriform cortex

Olfaction in social recognition memory

Olfaction in spatial learning

Expertise

Multi-electrode recordings in freely moving mice (silicon probes, tetrodes)

Optogenetics

Behavioral Assays (navigation, social behaviors...)

Stereotaxic surgeries (electrode implants, viral injections, canula placement)

In vivo pharmacology

Analysis of large neuronal datasets (LFP, spikes)

News

Lisa interviewed for article in Horizon Magazine

On the role of social scents. Article by Alex Whiting.

Lisa and Pascal contributed to "L'Enquête des Sens"

Chaque année, les étudiant·es du master Médiation des sciences de Bordeaux et l’association Dealers de Sciences organisent une semaine de culture scientifique et technique. Pour sa 5ème édition, la thématique choisie est « L’Enquête des Sens ». Lisa Roux et Pascal Ravassard ont répondu aux questions de leur interviewers sur la perception olfactive (https://www.lenquetedessens.dealersdescience.com/index.php/2020/10/03/les-serrures-de-lodorat/) et le lien entre mémoire et odorat (https://www.lenquetedessens.dealersdescience.com/index.php/2020/11/08/les-echos-de-la-memoire/).

Selected Publications

Roux L, Hu B, Eichler R, Stark E, Buzsáki G

Sharp wave ripples during learning stabilize the hippocampal spatial map Nature Neuroscience (2017) (2017)
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Stark E., Roux L., Eichler R., Buzsáki G.

Local generation of multi-neuronal spike sequences in the hippocampal CA1 region. PNAS (2015)
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Roux L., Madar A., Lacroix MM, Chenju Y., Benchenane K., Giaume C.

Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations. Journal of Neuroscience (2015)
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Stark E*, Roux L*, Eichler R*, Senzai Y, Royer S, Buzsáki G (*equal contribution)

Pyramidal cell-interneuron interactions underlie hippocampal ripple oscillations. Neuron (2014)
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Roux L., Benchenane K., Rothstein J., Bovento G., Giaume C.

Plasticity of astroglial networks in the olfactory glomeruli. PNAS (2011)
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Members

« Researcher »

ROUX Lisa

Researcher

lisa.roux@u-bordeaux.fr

+33533514851

« Technical Staff »

CADORET Marie-Anne	Technical staff	marie-anne.cadoret@u-bordeaux.fr	+33533514701
DOLIQUE Tiphaine	Technical staff	tiphaine.dolique@u-bordeaux.fr	+33533514852

« Postdoc »

CASALI Giulio	Postdoc	giulio.casali@u-bordeaux.fr	+33533514852
RAVASSARD Pascal	Postdoc	pascal.ravassard@u-bordeaux.fr	+33533514700
TERRAL Geoffrey	Postdoc	geoffrey.terral@u-bordeaux.fr	+33533514752