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Olfaction and Memory

Team Leader : Lisa Roux

Biosketch of Lisa Roux

 

General objective

Chemosensation is a fundamental sensory modality for living organisms, ranging from Bacteria to Mammals. It is used for many vital functions such as spatial navigation and communication with conspecifics. Odors can trigger innate behavioral responses, but most odor stimuli acquire behavioral significance upon learning and experience. The overarching goal of our team is to identify the neurophysiological substrates of olfactory memory formation across distributed brain networks.

To reach this goal, we study rodents in naturalistic conditions using cutting-edge technologies that allow recording and manipulating large neuronal ensembles in behaving animals: single unit extracellular recordings with silicon probes, closed-loop optogenetic strategies, automated behavioral tracking and precise monitoring of sniffing behavior.

Research Projects

Role of oxytocin in the piriform cortex

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Olfaction in social recognition memory

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Olfaction in spatial learning

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Expertise

  • Multi-electrode recordings in freely moving mice (silicon probes, tetrodes)
  • Optogenetics
  • Behavioral Assays (navigation, social behaviors...)
  • Stereotaxic surgeries (electrode implants, viral injections, canula placement)
  • In vivo pharmacology
  • Analysis of large neuronal datasets (LFP, spikes)
  • News

    Lisa interviewed for article in Horizon Magazine

    On the role of social scents. Article by Alex Whiting.

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    Lisa and Pascal contributed to "L'Enquête des Sens"

    Chaque année, les étudiant·es du master Médiation des sciences de Bordeaux et l’association Dealers de Sciences organisent une semaine de culture scientifique et technique. Pour sa 5ème édition, la thématique choisie est « L’Enquête des Sens ». Lisa Roux et Pascal Ravassard ont répondu aux questions de leur interviewers sur la perception olfactive (https://www.lenquetedessens.dealersdescience.com/index.php/2020/10/03/les-serrures-de-lodorat/) et le lien entre mémoire et odorat (https://www.lenquetedessens.dealersdescience.com/index.php/2020/11/08/les-echos-de-la-memoire/).

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    Selected Publications

  • Roux L, Hu B, Eichler R, Stark E, Buzsáki G
  • Sharp wave ripples during learning stabilize the hippocampal spatial map Nature Neuroscience (2017) (2017)
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  • Stark E., Roux L., Eichler R., Buzsáki G.
  • Local generation of multi-neuronal spike sequences in the hippocampal CA1 region. PNAS (2015)
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  • Roux L., Madar A., Lacroix MM, Chenju Y., Benchenane K., Giaume C.
  • Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations. Journal of Neuroscience (2015)
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  • Stark E*, Roux L*, Eichler R*, Senzai Y, Royer S, Buzsáki G (*equal contribution)
  • Pyramidal cell-interneuron interactions underlie hippocampal ripple oscillations. Neuron (2014)
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  • Roux L., Benchenane K., Rothstein J., Bovento G., Giaume C.
  • Plasticity of astroglial networks in the olfactory glomeruli. PNAS (2011)
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    Members

    « Researcher »

    ROUX Lisa Researcher lisa.roux@u-bordeaux.fr +33533514851

    « Technical Staff »

    CADORET Marie-Anne Technical staff marie-anne.cadoret@u-bordeaux.fr +33533514701
    DOLIQUE Tiphaine Technical staff tiphaine.dolique@u-bordeaux.fr +33533514852

    « Postdoc »

    CASALI Giulio Postdoc giulio.casali@u-bordeaux.fr +33533514852
    RAVASSARD Pascal Postdoc pascal.ravassard@u-bordeaux.fr +33533514700
    TERRAL Geoffrey Postdoc geoffrey.terral@u-bordeaux.fr +33533514752

    « PhD student »

    MIERMON Camille PhD student camille.miermon@etu.u-bordeaux.fr +33533514752

    « Student »

    MICHAUD Rafaël Student rafael.michaud@etu.u-bordeaux.fr +33533514700
    SCARABELLO Tessa Student tessa.scarabello@u-bordeaux.fr +33533514700

    « Alumni & Guests »

    • Edith Lesburguères, postdoc (2018-2020)
    • Léonie Henry, student (2020)
    • Louis Ware, student, Ecole Santé-Science de Bordeaux (2018)

    Jobs

    The team is hiring!

    Open postdoctoral position on ERC SociOlfa project. Motivated candidates can send their application and CV to: lisa.roux@u-bordeaux.fr

    Fundings

    Bordeaux Neurocampus
    IdEx of Bordeaux University
    ATIP-Avenir
    ERC Starting Grant: SociOlfa